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Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants
المؤلفون المشاركون
Ojha, Suvash Chandra
Younus, Muhammad
Zahoor, Adeela
Ibrahim, Muhammad
Nawaz, Sadia
Naseer, Rahat
Akram, Qaiser
Deng, Cun-Liang
Ahmed, Sarfraz
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The widespread adaptation of a new generation of direct-acting antiviral agents (DAAs) unveils a superlative effect in the eradication of the hepatitis C virus (HCV).
However, this therapy has been reported to exhibit vigorous side effects that pose a risk in fleet recovery.
This study was conducted to investigate the efficacy of DAAs: sofosbuvir (SOF) and ribavirin (RBV), along with black cumin (BLC) and ascorbate (ASC), as adjuvants on hematological parameters; oxidative stress markers such as total antioxidant status (TAS), superoxide dismutase (SOD), reduced (GSH) and oxidized (GSSG) glutathione (GSH), gamma-glutamyl transferase (GGT), and malondialdehyde (MDA); liver function markers such as aspartate transaminase (AST), alanine aminotransferase (ALT), bilirubin, and alkaline phosphatase (ALP); and viral load with determined genotypes.
HCV-infected patients (n=30) were randomly divided into two equal groups: control group (n=15) and treatment group (n=15).
The control group was subjected only to SOF and RBV (400 mg each/day).
Synergistically, the treatment group was administered with adjuvant therapy of BLC (250 mg/day) and ASC (1000 mg/day) along with DAAs (400 mg each/day) for 8 weeks.
All selected patients were subjected to sampling at pre- and posttreatment stages for the assessment of defined parameters.
The data revealed that the BLC/ASC adjuvant therapy boosted the efficacy of DAAs by reducing the elevated levels of liver markers such as AST, ALT, ALP, and bilirubin in the treatment group compared with those in the control group (P>0.05).
The adjuvant therapy synchronously showed an ameliorating effect on hematological parameters.
The SOF/RBV with adjuvant therapy also demonstrated an increasing effect in the activity of SOD, TAS, and GSH and a decreasing effect for GSSG, GGT, and malondialdehyde (MDA; P>0.05) followed by curtailing a RT-PCR-quantified viral load.
Our findings provide evidence that systemic administration of BLC/ASC efficiently alleviates hematological, serological, and antioxidant markers as well as the viral load in hepatitis C patients.
This highlights a potentially novel role of BLC and ASC in palliating hepatitis C.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmed, Sarfraz& Zahoor, Adeela& Ibrahim, Muhammad& Younus, Muhammad& Nawaz, Sadia& Naseer, Rahat…[et al.]. 2020. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmed, Sarfraz…[et al.]. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmed, Sarfraz& Zahoor, Adeela& Ibrahim, Muhammad& Younus, Muhammad& Nawaz, Sadia& Naseer, Rahat…[et al.]. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205282
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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