Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants
Joint Authors
Ojha, Suvash Chandra
Younus, Muhammad
Zahoor, Adeela
Ibrahim, Muhammad
Nawaz, Sadia
Naseer, Rahat
Akram, Qaiser
Deng, Cun-Liang
Ahmed, Sarfraz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The widespread adaptation of a new generation of direct-acting antiviral agents (DAAs) unveils a superlative effect in the eradication of the hepatitis C virus (HCV).
However, this therapy has been reported to exhibit vigorous side effects that pose a risk in fleet recovery.
This study was conducted to investigate the efficacy of DAAs: sofosbuvir (SOF) and ribavirin (RBV), along with black cumin (BLC) and ascorbate (ASC), as adjuvants on hematological parameters; oxidative stress markers such as total antioxidant status (TAS), superoxide dismutase (SOD), reduced (GSH) and oxidized (GSSG) glutathione (GSH), gamma-glutamyl transferase (GGT), and malondialdehyde (MDA); liver function markers such as aspartate transaminase (AST), alanine aminotransferase (ALT), bilirubin, and alkaline phosphatase (ALP); and viral load with determined genotypes.
HCV-infected patients (n=30) were randomly divided into two equal groups: control group (n=15) and treatment group (n=15).
The control group was subjected only to SOF and RBV (400 mg each/day).
Synergistically, the treatment group was administered with adjuvant therapy of BLC (250 mg/day) and ASC (1000 mg/day) along with DAAs (400 mg each/day) for 8 weeks.
All selected patients were subjected to sampling at pre- and posttreatment stages for the assessment of defined parameters.
The data revealed that the BLC/ASC adjuvant therapy boosted the efficacy of DAAs by reducing the elevated levels of liver markers such as AST, ALT, ALP, and bilirubin in the treatment group compared with those in the control group (P>0.05).
The adjuvant therapy synchronously showed an ameliorating effect on hematological parameters.
The SOF/RBV with adjuvant therapy also demonstrated an increasing effect in the activity of SOD, TAS, and GSH and a decreasing effect for GSSG, GGT, and malondialdehyde (MDA; P>0.05) followed by curtailing a RT-PCR-quantified viral load.
Our findings provide evidence that systemic administration of BLC/ASC efficiently alleviates hematological, serological, and antioxidant markers as well as the viral load in hepatitis C patients.
This highlights a potentially novel role of BLC and ASC in palliating hepatitis C.
American Psychological Association (APA)
Ahmed, Sarfraz& Zahoor, Adeela& Ibrahim, Muhammad& Younus, Muhammad& Nawaz, Sadia& Naseer, Rahat…[et al.]. 2020. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
Modern Language Association (MLA)
Ahmed, Sarfraz…[et al.]. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
American Medical Association (AMA)
Ahmed, Sarfraz& Zahoor, Adeela& Ibrahim, Muhammad& Younus, Muhammad& Nawaz, Sadia& Naseer, Rahat…[et al.]. Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205282