Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion
المؤلفون المشاركون
Fan, Xin
Yang, Bo
Zhou, Jun
Du, Juan
Wang, Mao-Hua
Li, Jia-Man
Chen, Ye
Dai, Jun-Chao
Zhang, Chunxiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Intestinal ischemia/reperfusion (I/R), which is associated with high morbidity and mortality, is also accompanied with abnormal energy metabolism and liver injury.
Irisin, a novel exercise-induced hormone, can regulate adipose browning and thermogenesis.
The following study investigated the potential role of dexmedetomidine in liver injury during intestinal I/R in rats.
Adult male Sprague–Dawley rats underwent occlusion of the superior mesenteric artery for 90 min followed by 2 h of reperfusion.
Dexmedetomidine or irisin-neutralizing antibody was intravenously administered for 1 h before surgery.
The results demonstrated that severe intestine and liver injuries occurred during intestinal I/R as evidenced by pathological scores and an apparent increase in serum diamine oxidase (DAO), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels.
In addition, the hepatic irisin, cleaved caspase-3, Bax, and NLRP3 inflammasome components (including NLRP3, ASC, and caspase-1), protein expressions, apoptotic index, reactive oxygen species (ROS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 levels increased; however, the serum irisin level and hepatic Bcl-2 protein expression and superoxide dismutase (SOD) activity decreased after intestinal I/R.
Interestingly, dexmedetomidine could reduce the above listed changes and increase the irisin levels in plasma and the liver in I/R rats.
Dexmedetomidine-mediated protective effects on liver injury and NLRP3 inflammasome activation during intestinal I/R were partially abrogated via irisin-neutralizing antibody treatment.
The results suggest that irisin might contribute to the hepatoprotection of dexmedetomidine during intestinal ischemia/reperfusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Xin& Du, Juan& Wang, Mao-Hua& Li, Jia-Man& Yang, Bo& Chen, Ye…[et al.]. 2019. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Xin…[et al.]. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Xin& Du, Juan& Wang, Mao-Hua& Li, Jia-Man& Yang, Bo& Chen, Ye…[et al.]. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205309
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر