Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion
Joint Authors
Fan, Xin
Yang, Bo
Zhou, Jun
Du, Juan
Wang, Mao-Hua
Li, Jia-Man
Chen, Ye
Dai, Jun-Chao
Zhang, Chunxiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Intestinal ischemia/reperfusion (I/R), which is associated with high morbidity and mortality, is also accompanied with abnormal energy metabolism and liver injury.
Irisin, a novel exercise-induced hormone, can regulate adipose browning and thermogenesis.
The following study investigated the potential role of dexmedetomidine in liver injury during intestinal I/R in rats.
Adult male Sprague–Dawley rats underwent occlusion of the superior mesenteric artery for 90 min followed by 2 h of reperfusion.
Dexmedetomidine or irisin-neutralizing antibody was intravenously administered for 1 h before surgery.
The results demonstrated that severe intestine and liver injuries occurred during intestinal I/R as evidenced by pathological scores and an apparent increase in serum diamine oxidase (DAO), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels.
In addition, the hepatic irisin, cleaved caspase-3, Bax, and NLRP3 inflammasome components (including NLRP3, ASC, and caspase-1), protein expressions, apoptotic index, reactive oxygen species (ROS), malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 levels increased; however, the serum irisin level and hepatic Bcl-2 protein expression and superoxide dismutase (SOD) activity decreased after intestinal I/R.
Interestingly, dexmedetomidine could reduce the above listed changes and increase the irisin levels in plasma and the liver in I/R rats.
Dexmedetomidine-mediated protective effects on liver injury and NLRP3 inflammasome activation during intestinal I/R were partially abrogated via irisin-neutralizing antibody treatment.
The results suggest that irisin might contribute to the hepatoprotection of dexmedetomidine during intestinal ischemia/reperfusion.
American Psychological Association (APA)
Fan, Xin& Du, Juan& Wang, Mao-Hua& Li, Jia-Man& Yang, Bo& Chen, Ye…[et al.]. 2019. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
Modern Language Association (MLA)
Fan, Xin…[et al.]. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
American Medical Association (AMA)
Fan, Xin& Du, Juan& Wang, Mao-Hua& Li, Jia-Man& Yang, Bo& Chen, Ye…[et al.]. Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal IschemiaReperfusion. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1205309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205309