The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats
المؤلفون المشاركون
Liu, Cui
Lv, Weijie
Chao, Limin
Guo, Shining
Zhou, Jia-hao
Guo, Ao
Wu, Xiao-ling
Chen, Wen-qian
Li, Yue-fei
Zhang, Gui-feng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Generally, depression is the result of complex gene-environment interactions.
Recent studies have showed that the gut microbiota can affect brain function through the microbiota-gut-brain axis.
However, the underlying mechanism of the microbiota and potential influence of depression remain elusive.
We aimed to determine how gut microbiome contributes to the process of depression and further influences the host.
Chronic unpredictable mild stress (CUMS) is used to establish a depression model.
Fecal microbiota transplant (FMT) is applied to illustrate that depression can be transmitted via microbiota, and metabolism of liver analysis is applied to demonstrate further influence to the liver.
We also analyzed the astrocyte activation in the brain by immunofluorescence (IF).
Here, we show that the structure of the gut microbiome changes markedly after rats undergo CUMS.
Notably, we found that the ratio of Lactobacillus to Clostridium can be a vital index for the development of depression.
Depression-like behavior can be duplicated through FMT.
Moreover, increased zonulin and fatty acid binding protein-2 indicates that gut barrier integrity is broken after FMT.
Subsequently, metabolomics shows that liver metabolic disorder occurs and leads to liver coagulative necrosis.
In addition, increased inflammatory cytokine expression and higher astrocyte activation indicate an inflammatory process in the brain.
These findings suggest that dysbiosis gut microbiome contributes to development of depression and further causes liver metabolic disorders in a way that may be relevant to the Lactobacillus to Clostridium ratio.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Weijie& Wu, Xiao-ling& Chen, Wen-qian& Li, Yue-fei& Zhang, Gui-feng& Chao, Limin…[et al.]. 2019. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Weijie…[et al.]. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Weijie& Wu, Xiao-ling& Chen, Wen-qian& Li, Yue-fei& Zhang, Gui-feng& Chao, Limin…[et al.]. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205343
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر