The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats
Joint Authors
Liu, Cui
Lv, Weijie
Chao, Limin
Guo, Shining
Zhou, Jia-hao
Guo, Ao
Wu, Xiao-ling
Chen, Wen-qian
Li, Yue-fei
Zhang, Gui-feng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Generally, depression is the result of complex gene-environment interactions.
Recent studies have showed that the gut microbiota can affect brain function through the microbiota-gut-brain axis.
However, the underlying mechanism of the microbiota and potential influence of depression remain elusive.
We aimed to determine how gut microbiome contributes to the process of depression and further influences the host.
Chronic unpredictable mild stress (CUMS) is used to establish a depression model.
Fecal microbiota transplant (FMT) is applied to illustrate that depression can be transmitted via microbiota, and metabolism of liver analysis is applied to demonstrate further influence to the liver.
We also analyzed the astrocyte activation in the brain by immunofluorescence (IF).
Here, we show that the structure of the gut microbiome changes markedly after rats undergo CUMS.
Notably, we found that the ratio of Lactobacillus to Clostridium can be a vital index for the development of depression.
Depression-like behavior can be duplicated through FMT.
Moreover, increased zonulin and fatty acid binding protein-2 indicates that gut barrier integrity is broken after FMT.
Subsequently, metabolomics shows that liver metabolic disorder occurs and leads to liver coagulative necrosis.
In addition, increased inflammatory cytokine expression and higher astrocyte activation indicate an inflammatory process in the brain.
These findings suggest that dysbiosis gut microbiome contributes to development of depression and further causes liver metabolic disorders in a way that may be relevant to the Lactobacillus to Clostridium ratio.
American Psychological Association (APA)
Lv, Weijie& Wu, Xiao-ling& Chen, Wen-qian& Li, Yue-fei& Zhang, Gui-feng& Chao, Limin…[et al.]. 2019. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
Modern Language Association (MLA)
Lv, Weijie…[et al.]. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
American Medical Association (AMA)
Lv, Weijie& Wu, Xiao-ling& Chen, Wen-qian& Li, Yue-fei& Zhang, Gui-feng& Chao, Limin…[et al.]. The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205343