Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax
المؤلفون المشاركون
Zeng, Ke-Wu
Zhao, Shaoyang
Li, Weiwei
Liao, Li-Xi
Tu, Peng-Fei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Diabetic encephalopathy (DE) is a serious complication caused by long-term cognitive impairment in diabetic patients.
At present, there is no effective treatment for DE.
Icariin (ICA) is a bioactive ingredient isolated from Epimedium.
Previous research indicated that ICA was neuroprotective against Aβ-induced PC12 cell insult; however, the effect of ICA on an advanced glycosylation end product- (AGE-) induced neural injury model has not been studied.
In this study, we investigated the neuroprotective effects of ICA on AGE-induced injury in PC12 cells.
Our findings revealed that ICA could effectively protect PC12 cells from AGE-induced cell apoptosis by suppressing oxidative stress.
Moreover, we observed that ICA could significantly protect against mitochondrial depolarization following AGE stimulation and inactivate the mitochondria-dependent caspase-9/3 apoptosis pathway.
Most notably, we identified the direct target protein of ICA as apoptosis regulator Bax by a pulldown assay.
We found that ICA could specifically target Bax protein and inhibit Bax dimer formation and migration to mitochondria.
Furthermore, a siRNA knockdown experiment revealed that ICA could inhibit PC12 cell apoptosis and oxidative stress through targeting Bax.
Taken together, our findings demonstrated that ICA could attenuate AGE-induced oxidative stress and mitochondrial apoptosis by specifically targeting Bax and further regulating the biological function of Bax on mitochondria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Shaoyang& Liao, Li-Xi& Tu, Peng-Fei& Li, Weiwei& Zeng, Ke-Wu. 2019. Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Shaoyang…[et al.]. Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Shaoyang& Liao, Li-Xi& Tu, Peng-Fei& Li, Weiwei& Zeng, Ke-Wu. Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر