Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell
المؤلفون المشاركون
Chen, Min
Chen, Min
Chen, Suren
Zhou, Jingjing
Dong, Fangfang
Shen, Zhiming
Wu, Haowei
Cui, Xiuhong
Gao, Fei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The interaction between germ cell and somatic cell plays important roles in germ cell development.
However, the exact function of gonad somatic cell in germ cell differentiation is unclear.
In the present study, the function of gonad somatic cell in germ cell meiosis was examined by using mouse models with aberrant somatic cell differentiation.
In Wt1R394W/R394W mice, the genital ridge is absent due to the apoptosis of coelomic epithelial cells.
Interestingly, in both male and female Wt1R394W/R394W germ cells, STRA8 was detected at E12.5 and the scattered SYCP3 foci were observed at E13.5 which was consistent with control females.
In Wt1-/flox; Cre-ERTM mice, Wt1 was inactivated by the injection of tamoxifen at E9.5 and the differentiation of Sertoli and granulosa cells was completely blocked.
We found that most germ cells were located outside of genital ridge after Wt1 inactivation.
STRA8, SYCP3, and γH2AX proteins were detected in germ cells of both male and female Wt1-/flox; Cre-ERTM gonads, whereas no thread-like SYCP3 signal was observed.
Our study demonstrates that aberrant development of gonad somatic cells leads to ectopic expression of meiosis-associated genes in germ cells, but meiosis was arrested before prophase I.
These results suggest that the proper differentiation of gonad somatic cells is essential for germ cell meiosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Min& Chen, Min& Chen, Suren& Zhou, Jingjing& Dong, Fangfang& Shen, Zhiming…[et al.]. 2019. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1205404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Min…[et al.]. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1205404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Min& Chen, Min& Chen, Suren& Zhou, Jingjing& Dong, Fangfang& Shen, Zhiming…[et al.]. Abnormal Meiosis Initiation in Germ Cell Caused by Aberrant Differentiation of Gonad Somatic Cell. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1205404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر