Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence
المؤلفون المشاركون
Lee, Tae Won
Kim, Jin Hyun
Jung, Myeong Hee
Bae, Eunjin
Jang, Si Jung
Jung, Sehyun
Lee, Seunghye
Jang, Ha Nee
Chang, Se-Ho
Park, Dong Jun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%.
However, the disease mechanism remains unclear, and no effective treatment is available.
Paricalcitol has been reported to be effective in animal models of kidney injury.
We hypothesized that paricalcitol could play a renoprotective role against CI-AKI.
Rats were divided into control, paricalcitol, contrast, and paricalcitol-plus-contrast groups.
We used a previously published protocol to produce CI-AKI.
Paricalcitol (0.3 μg/kg) was administered intraperitoneally before 24 h and 30 min before indomethacin.
We used HK-2 cells to evaluate the effects of paricalcitol on mitophagy and senescence.
Ioversol triggered renal dysfunction, increasing blood urea nitrogen and serum creatinine.
Significant tubular damage, increased 8-OHdG expression, and apoptosis were apparent.
Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers β-galactosidase and p16INK4A.
Paricalcitol pretreatment prevented renal dysfunction and reduced tissue damage by reducing both mitophagy and senescence.
Cellular morphological changes were found, and expression of LC3B and HMGB1 was increased by ioversol in HK-2 cells.
Paricalcitol countered these effects.
This study showed that mitochondria might drive injury phenotypes in CI-AKI, and that paricalcitol protects against CI-AKI by decreasing mitochondrial damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bae, Eunjin& Kim, Jin Hyun& Jung, Myeong Hee& Jang, Si Jung& Lee, Tae Won& Jung, Sehyun…[et al.]. 2020. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205407
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bae, Eunjin…[et al.]. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205407
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bae, Eunjin& Kim, Jin Hyun& Jung, Myeong Hee& Jang, Si Jung& Lee, Tae Won& Jung, Sehyun…[et al.]. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205407
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205407
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر