Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence

Joint Authors

Lee, Tae Won
Kim, Jin Hyun
Jung, Myeong Hee
Bae, Eunjin
Jang, Si Jung
Jung, Sehyun
Lee, Seunghye
Jang, Ha Nee
Chang, Se-Ho
Park, Dong Jun

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-23

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology

Abstract EN

Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%.

However, the disease mechanism remains unclear, and no effective treatment is available.

Paricalcitol has been reported to be effective in animal models of kidney injury.

We hypothesized that paricalcitol could play a renoprotective role against CI-AKI.

Rats were divided into control, paricalcitol, contrast, and paricalcitol-plus-contrast groups.

We used a previously published protocol to produce CI-AKI.

Paricalcitol (0.3 μg/kg) was administered intraperitoneally before 24 h and 30 min before indomethacin.

We used HK-2 cells to evaluate the effects of paricalcitol on mitophagy and senescence.

Ioversol triggered renal dysfunction, increasing blood urea nitrogen and serum creatinine.

Significant tubular damage, increased 8-OHdG expression, and apoptosis were apparent.

Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers β-galactosidase and p16INK4A.

Paricalcitol pretreatment prevented renal dysfunction and reduced tissue damage by reducing both mitophagy and senescence.

Cellular morphological changes were found, and expression of LC3B and HMGB1 was increased by ioversol in HK-2 cells.

Paricalcitol countered these effects.

This study showed that mitochondria might drive injury phenotypes in CI-AKI, and that paricalcitol protects against CI-AKI by decreasing mitochondrial damage.

American Psychological Association (APA)

Bae, Eunjin& Kim, Jin Hyun& Jung, Myeong Hee& Jang, Si Jung& Lee, Tae Won& Jung, Sehyun…[et al.]. 2020. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205407

Modern Language Association (MLA)

Bae, Eunjin…[et al.]. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205407

American Medical Association (AMA)

Bae, Eunjin& Kim, Jin Hyun& Jung, Myeong Hee& Jang, Si Jung& Lee, Tae Won& Jung, Sehyun…[et al.]. Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205407

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1205407