Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTPMPP+-Induced Toxicity via Progesterone Receptor Signaling
المؤلفون المشاركون
Zhao, Yingke
Lee, Simon Ming-Yuen
Luo, Dan
Cheng, Yuanyuan
Rong, Jianhui
Zhao, Jia
Zhang, Xiuying
Lao, Lixing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Progesterone receptor (PR) modulates neuroprotective and regenerative responses in Parkinson’s disease and related neurological diseases.
Objectives.
The present study was designed to determine whether botanical drug puerarin could exhibit neuroprotective and neurorestorative activities via PR signaling.
Methods.
The neuroprotective and neurotrophic activities of puerarin were investigated in MPTP-lesioned mice and MPP+-challenged primary rat midbrain neurons.
Rotarod performance test and tail suspension test were used to assess motor functions.
Tyrosine hydroxylase (TH) and PR were determined by immunostaining, Western blotting, and luciferase reporter assays.
Neurite outgrowth was assessed by fluorescence staining and immunostaining.
Results.
Puerarin effectively ameliorated the MPTP-induced motor abnormalities in MPTP-lesioned mice and protected primary rat midbrain neurons against MPP+-induced toxicity via PR signaling although progesterone exhibited the neuroprotection.
PR antagonist mifepristone (RU486) diminished the neuroprotection of puerarin in MPTP-lesioned mice and MPP+-induced primary rat midbrain neurons.
Moreover, puerarin promoted the differentiation of primary rat midbrain neurons and potentiated NGF to induce neuritogenesis in PC12 cells.
RU486 and PR-siRNA could inhibit the effect of puerarin.
Puerarin and progesterone could enhance the PR promoter.
Conclusion.
Puerarin attenuated MPTP- and MPP+-induced toxicity and potentiated neurite outgrowth via PR.
These results suggested that puerarin may become an alternative hormone for suppressing MPTP- and MPP+-induced toxicity in neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Yingke& Zhao, Jia& Zhang, Xiuying& Cheng, Yuanyuan& Luo, Dan& Lee, Simon Ming-Yuen…[et al.]. 2020. Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTPMPP+-Induced Toxicity via Progesterone Receptor Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205410
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Yingke…[et al.]. Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTPMPP+-Induced Toxicity via Progesterone Receptor Signaling. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205410
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Yingke& Zhao, Jia& Zhang, Xiuying& Cheng, Yuanyuan& Luo, Dan& Lee, Simon Ming-Yuen…[et al.]. Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTPMPP+-Induced Toxicity via Progesterone Receptor Signaling. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205410
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205410
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر