Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen
المؤلفون المشاركون
Hu, Xueyuan
Li, Shu
Chi, Qianru
Wang, Dongxu
Li, Shiping
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hydrogen sulfide (H2S) is one of the main pollutants in the atmosphere, which is a serious threat to human health.
The decomposition of sulfur-containing organics in chicken houses could produce a large amount of H2S, thereby damaging poultry health.
In this study, one-day-old broilers were selected and exposed to 4 or 20 ppm of H2S gas (0-3 weeks: 4±0.5 ppm, 4-6 weeks: 20±0.5 ppm).
The spleen samples were collected immediately after the chickens were euthanized at 2, 4, and 6 weeks.
The histopathological and ultrastructural observations showed obvious necrosis characteristics of H2S-exposed spleens.
H2S exposure suppressed GSH, CAT, T-AOC, and SOD activities; increased NO, H2O2, and MDA content and iNOS activity; and induced oxidative stress.
ATPase activities and the expressions of energy metabolism-related genes were significantly decreased.
Also, the expressions of related necroptosis (RIPK1, RIPK3, MLKL, TAK1, TAB2, and TAB3) were significantly increased, and the MAPK pathway was activated.
Besides, H2S exposure activated the NF-κB classical pathway and induced TNF-α and IL-1β release.
Taken together, we conclude that H2S exposure induces oxidative stress and energy metabolism dysfunction; evokes necroptosis; activates the MAPK pathway, eventually triggering the NF-κB pathway; and promotes inflammatory response in chicken spleens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chi, Qianru& Wang, Dongxu& Hu, Xueyuan& Li, Shiping& Li, Shu. 2019. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chi, Qianru…[et al.]. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chi, Qianru& Wang, Dongxu& Hu, Xueyuan& Li, Shiping& Li, Shu. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر