Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen
Joint Authors
Hu, Xueyuan
Li, Shu
Chi, Qianru
Wang, Dongxu
Li, Shiping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) is one of the main pollutants in the atmosphere, which is a serious threat to human health.
The decomposition of sulfur-containing organics in chicken houses could produce a large amount of H2S, thereby damaging poultry health.
In this study, one-day-old broilers were selected and exposed to 4 or 20 ppm of H2S gas (0-3 weeks: 4±0.5 ppm, 4-6 weeks: 20±0.5 ppm).
The spleen samples were collected immediately after the chickens were euthanized at 2, 4, and 6 weeks.
The histopathological and ultrastructural observations showed obvious necrosis characteristics of H2S-exposed spleens.
H2S exposure suppressed GSH, CAT, T-AOC, and SOD activities; increased NO, H2O2, and MDA content and iNOS activity; and induced oxidative stress.
ATPase activities and the expressions of energy metabolism-related genes were significantly decreased.
Also, the expressions of related necroptosis (RIPK1, RIPK3, MLKL, TAK1, TAB2, and TAB3) were significantly increased, and the MAPK pathway was activated.
Besides, H2S exposure activated the NF-κB classical pathway and induced TNF-α and IL-1β release.
Taken together, we conclude that H2S exposure induces oxidative stress and energy metabolism dysfunction; evokes necroptosis; activates the MAPK pathway, eventually triggering the NF-κB pathway; and promotes inflammatory response in chicken spleens.
American Psychological Association (APA)
Chi, Qianru& Wang, Dongxu& Hu, Xueyuan& Li, Shiping& Li, Shu. 2019. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
Modern Language Association (MLA)
Chi, Qianru…[et al.]. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
American Medical Association (AMA)
Chi, Qianru& Wang, Dongxu& Hu, Xueyuan& Li, Shiping& Li, Shu. Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPKNF-κB Pathway in Broiler Spleen. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205433