The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
المؤلفون المشاركون
Yang, Zehong
Liu, Changhui
Gao, Zhao
Zhang, Jiecheng
Wei, Li
Yang, Xingping
Zhang, Yuan
Cheng, Bo
Gao, Weihang
Song, Chunhui
Miao, Wei
Williams, Kevin
Xu, Qin
Chang, Yongsheng
Gao, Yong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-13
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis.
Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects.
However, its potential to ameliorate ALI is unknown.
In this study, APAP-treated genetic knockout of Farnesoid X receptor (FXR) and Sirtuin 1 (SIRT1) mice were used for research.
The results revealed that IMP could improve the severity of liver injury and inhibit the increase of proinflammatory cytokines, oxidative damage, and apoptosis induced by overdose APAP in an FXR-dependent manner.
We also found that IMP enhanced the activation and translocation of FXR by increasing the expression of SIRT1 and the phosphorylation of AMPK.
Besides, single administration of IMP at 4 h after APAP injection can also improve necrotic areas and serum transaminase, indicating that IMP have both preventive and therapeutic effects.
Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway.
These findings suggest that IMP is a potential therapeutic candidate for ALI, offering promise for the treatment of hepatotoxicity associated with APAP overdose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gao, Zhao& Zhang, Jiecheng& Wei, Li& Yang, Xingping& Zhang, Yuan& Cheng, Bo…[et al.]. 2020. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gao, Zhao…[et al.]. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gao, Zhao& Zhang, Jiecheng& Wei, Li& Yang, Xingping& Zhang, Yuan& Cheng, Bo…[et al.]. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205500
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر