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The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
Joint Authors
Yang, Zehong
Liu, Changhui
Gao, Zhao
Zhang, Jiecheng
Wei, Li
Yang, Xingping
Zhang, Yuan
Cheng, Bo
Gao, Weihang
Song, Chunhui
Miao, Wei
Williams, Kevin
Xu, Qin
Chang, Yongsheng
Gao, Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis.
Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects.
However, its potential to ameliorate ALI is unknown.
In this study, APAP-treated genetic knockout of Farnesoid X receptor (FXR) and Sirtuin 1 (SIRT1) mice were used for research.
The results revealed that IMP could improve the severity of liver injury and inhibit the increase of proinflammatory cytokines, oxidative damage, and apoptosis induced by overdose APAP in an FXR-dependent manner.
We also found that IMP enhanced the activation and translocation of FXR by increasing the expression of SIRT1 and the phosphorylation of AMPK.
Besides, single administration of IMP at 4 h after APAP injection can also improve necrotic areas and serum transaminase, indicating that IMP have both preventive and therapeutic effects.
Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway.
These findings suggest that IMP is a potential therapeutic candidate for ALI, offering promise for the treatment of hepatotoxicity associated with APAP overdose.
American Psychological Association (APA)
Gao, Zhao& Zhang, Jiecheng& Wei, Li& Yang, Xingping& Zhang, Yuan& Cheng, Bo…[et al.]. 2020. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
Modern Language Association (MLA)
Gao, Zhao…[et al.]. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
American Medical Association (AMA)
Gao, Zhao& Zhang, Jiecheng& Wei, Li& Yang, Xingping& Zhang, Yuan& Cheng, Bo…[et al.]. The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205500