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Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia
المؤلفون المشاركون
Yu, Kun
Yao, Yuchang
Zhang, Xiaosheng
Liu, Yixun
Lian, Zhengxing
Wang, Rong-Xiang
Li, Meng-Hui
Sun, Tie-Cheng
Zhou, Yi-Wen
Li, Yuan-Yuan
Zhang, Bao-Lu
Xue, Song-Guo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background/Aims.
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal hormone levels in peripheral blood and poor-quality oocytes.
PCOS is a pathophysiological syndrome caused by chronic inflammation and oxidative stress.
The aim of this study was to investigate the mechanism of melatonin regulation on androgen production and antioxidative damage in granulosa cells from PCOS patients with hypoestrogenia and hyperandrogenia.
Methods.
Cumulus-oocyte complexes were collected from PCOS patients who had low levels of estrogen in follicular fluids.
Results.
Melatonin triggered upregulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) expression via the extracellular signal-regulated kinase pathway in luteinized granulosa cells.
As a result, conversion of androgen to 17β-estradiol was accelerated.
We also found that melatonin significantly reduced the levels of inducible nitric oxide (NO) synthetase and NO in luteinized granulosa cells.
Levels of transcripts encoding NF-E2-related factor-2 and its downstream target heme oxygenase-1 were also increased, leading to anti-inflammatory and antioxidant effects.
We also found that melatonin could improve oocyte development potential.
Conclusion.
Our preliminary results showed that melatonin had a positive impact on oocyte quality in PCOS patients with hypoestrogenia and hyperandrogenia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Kun& Wang, Rong-Xiang& Li, Meng-Hui& Sun, Tie-Cheng& Zhou, Yi-Wen& Li, Yuan-Yuan…[et al.]. 2019. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Kun…[et al.]. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Kun& Wang, Rong-Xiang& Li, Meng-Hui& Sun, Tie-Cheng& Zhou, Yi-Wen& Li, Yuan-Yuan…[et al.]. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205552
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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