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Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia
Joint Authors
Yu, Kun
Yao, Yuchang
Zhang, Xiaosheng
Liu, Yixun
Lian, Zhengxing
Wang, Rong-Xiang
Li, Meng-Hui
Sun, Tie-Cheng
Zhou, Yi-Wen
Li, Yuan-Yuan
Zhang, Bao-Lu
Xue, Song-Guo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background/Aims.
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by abnormal hormone levels in peripheral blood and poor-quality oocytes.
PCOS is a pathophysiological syndrome caused by chronic inflammation and oxidative stress.
The aim of this study was to investigate the mechanism of melatonin regulation on androgen production and antioxidative damage in granulosa cells from PCOS patients with hypoestrogenia and hyperandrogenia.
Methods.
Cumulus-oocyte complexes were collected from PCOS patients who had low levels of estrogen in follicular fluids.
Results.
Melatonin triggered upregulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) expression via the extracellular signal-regulated kinase pathway in luteinized granulosa cells.
As a result, conversion of androgen to 17β-estradiol was accelerated.
We also found that melatonin significantly reduced the levels of inducible nitric oxide (NO) synthetase and NO in luteinized granulosa cells.
Levels of transcripts encoding NF-E2-related factor-2 and its downstream target heme oxygenase-1 were also increased, leading to anti-inflammatory and antioxidant effects.
We also found that melatonin could improve oocyte development potential.
Conclusion.
Our preliminary results showed that melatonin had a positive impact on oocyte quality in PCOS patients with hypoestrogenia and hyperandrogenia.
American Psychological Association (APA)
Yu, Kun& Wang, Rong-Xiang& Li, Meng-Hui& Sun, Tie-Cheng& Zhou, Yi-Wen& Li, Yuan-Yuan…[et al.]. 2019. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
Modern Language Association (MLA)
Yu, Kun…[et al.]. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
American Medical Association (AMA)
Yu, Kun& Wang, Rong-Xiang& Li, Meng-Hui& Sun, Tie-Cheng& Zhou, Yi-Wen& Li, Yuan-Yuan…[et al.]. Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205552