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The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
المؤلفون المشاركون
Zhang, Yuxin
Cheng, Kun
Cai, Ning
Zhu, Jinghan
Xiong, Yixiao
Wen, Jingyuan
Liang, Huifang
Zhang, Wanguang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy.
Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system’s failure.
The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids.
Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology.
Targeting ferroptosis may be an effective and selective way for cancer therapy.
The underlying molecular mechanism of ferroptosis occurrence is still not enough.
This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade.
Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism.
The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described.
Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Jinghan& Xiong, Yixiao& Zhang, Yuxin& Wen, Jingyuan& Cai, Ning& Cheng, Kun…[et al.]. 2020. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Jinghan…[et al.]. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Jinghan& Xiong, Yixiao& Zhang, Yuxin& Wen, Jingyuan& Cai, Ning& Cheng, Kun…[et al.]. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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