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The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
Joint Authors
Zhang, Yuxin
Cheng, Kun
Cai, Ning
Zhu, Jinghan
Xiong, Yixiao
Wen, Jingyuan
Liang, Huifang
Zhang, Wanguang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy.
Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system’s failure.
The sensitivity of ferroptosis is tightly regulated by a series of biological processes, the metabolism of iron, amino acids, and polyunsaturated fatty acids, and the interaction of glutathione (GSH), NADPH, coenzyme Q10 (CoQ10), and phospholipids.
Elevated oxidative stress (ROS) level is a hallmark of cancer, and ferroptosis serves as a link between nutrition metabolism and redox biology.
Targeting ferroptosis may be an effective and selective way for cancer therapy.
The underlying molecular mechanism of ferroptosis occurrence is still not enough.
This review will briefly summarize the process of ferroptosis and introduce critical molecules in the ferroptotic cascade.
Furthermore, we reviewed the occurrence and regulation of reduction-oxidation (redox) for ferroptosis in cancer metabolism.
The role of the tumor suppressor and the epigenetic regulator in tumor cell ferroptosis will also be described.
Finally, old drugs that can be repurposed to induce ferroptosis will be characterized, aiming for drug repurposing and novel drug combinations for cancer therapy more efficiently and economically.
American Psychological Association (APA)
Zhu, Jinghan& Xiong, Yixiao& Zhang, Yuxin& Wen, Jingyuan& Cai, Ning& Cheng, Kun…[et al.]. 2020. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
Modern Language Association (MLA)
Zhu, Jinghan…[et al.]. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
American Medical Association (AMA)
Zhu, Jinghan& Xiong, Yixiao& Zhang, Yuxin& Wen, Jingyuan& Cai, Ning& Cheng, Kun…[et al.]. The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205698