Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition
المؤلفون المشاركون
Chung, Hwan-Suck
Kim, Ji Hye
Kim, Young Soo
Choi, Jang-Gi
Li, Wei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-05
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Antigenic mismatch can cause influenza vaccines to be ineffective, and influenza viruses resistant to antiviral drugs are rising.
Thus, development of antiviral agents against these viruses is an immediate need.
Rhus verniciflua (RVS) has long been used in herbal medicine and as a nutritional supplement.
The effect of RVS and its components on influenza virus has not, however, been reported.
We found that RVS treatment significantly reduced viral replication when evaluated with green fluorescent protein- (GFP-) tagged virus (influenza A virus, A/PR/8/34-GFP) in Madin–Darby canine kidney (MDCK) cells.
RVS showed significant inhibition of neuraminidase from A/PR/8/34.
Subsequently, three fractions were prepared from an ethanolic crude extract of RVS.
In vitro assays indicated that an ethyl acetate fraction (RVSE) was more potent than H2O and CHCl3 fractions.
RVSE significantly suppressed influenza virus infection in MDCK cells via neuraminidase inhibition.
Additionally, RVSE treatment inhibited expression of several virus proteins and decreased mortality of mice exposed to influenza A/PR/8/34 by 50% and reduced weight loss by 11.5%.
Active components in RVSE were isolated, and 5-deoxyluteolin (5) and sulfuretin (7) demonstrate the highest neuraminidase inhibitory activity against influenza A virus.
RVS, RVSE, and their constituents may be useful for the development of anti-influenza agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Young Soo& Li, Wei& Kim, Ji Hye& Chung, Hwan-Suck& Choi, Jang-Gi. 2020. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Young Soo…[et al.]. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Young Soo& Li, Wei& Kim, Ji Hye& Chung, Hwan-Suck& Choi, Jang-Gi. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205737
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر