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Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition
Joint Authors
Chung, Hwan-Suck
Kim, Ji Hye
Kim, Young Soo
Choi, Jang-Gi
Li, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Antigenic mismatch can cause influenza vaccines to be ineffective, and influenza viruses resistant to antiviral drugs are rising.
Thus, development of antiviral agents against these viruses is an immediate need.
Rhus verniciflua (RVS) has long been used in herbal medicine and as a nutritional supplement.
The effect of RVS and its components on influenza virus has not, however, been reported.
We found that RVS treatment significantly reduced viral replication when evaluated with green fluorescent protein- (GFP-) tagged virus (influenza A virus, A/PR/8/34-GFP) in Madin–Darby canine kidney (MDCK) cells.
RVS showed significant inhibition of neuraminidase from A/PR/8/34.
Subsequently, three fractions were prepared from an ethanolic crude extract of RVS.
In vitro assays indicated that an ethyl acetate fraction (RVSE) was more potent than H2O and CHCl3 fractions.
RVSE significantly suppressed influenza virus infection in MDCK cells via neuraminidase inhibition.
Additionally, RVSE treatment inhibited expression of several virus proteins and decreased mortality of mice exposed to influenza A/PR/8/34 by 50% and reduced weight loss by 11.5%.
Active components in RVSE were isolated, and 5-deoxyluteolin (5) and sulfuretin (7) demonstrate the highest neuraminidase inhibitory activity against influenza A virus.
RVS, RVSE, and their constituents may be useful for the development of anti-influenza agents.
American Psychological Association (APA)
Kim, Young Soo& Li, Wei& Kim, Ji Hye& Chung, Hwan-Suck& Choi, Jang-Gi. 2020. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
Modern Language Association (MLA)
Kim, Young Soo…[et al.]. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
American Medical Association (AMA)
Kim, Young Soo& Li, Wei& Kim, Ji Hye& Chung, Hwan-Suck& Choi, Jang-Gi. Anti-Influenza Activity of an Ethyl Acetate Fraction of a Rhus verniciflua Ethanol Extract by Neuraminidase Inhibition. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205737