Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke
المؤلفون المشاركون
Liu, Xinfeng
Xie, Yi
Liu, Qian
Zhang, Xiaohao
Shi, Xiaolei
Xu, Pengfei
Hong, Ye
Li, Juanji
Peng, Mengna
Xu, Gelin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Transplantation of neural stem cells (NSCs) is a promising therapy for ischemic stroke.
However, the effectiveness of this approach is limited by grafted cell death.
Breast cancer susceptibility protein 1 (BRCA1) could suppress apoptosis in neural progenitors and modulate oxidative stress in neurons.
In this study, we found that BRCA1 was upregulated by oxygen-glucose deprivation/reoxygenation (OGD/R).
Overexpression of BRCA1 in NSCs reduced cell apoptosis and oxidative stress after OGD/R insult.
The molecule overexpression also stimulated cellular proliferation in OGD/R NSCs and increased the survival rate of grafted cells.
Further, the transplantation of BRCA1-transfected NSCs into mice with ischemic stroke increased brain-derived neurotropic factor and nerve growth factor expression in the brain and elicited neurological function improvement.
In addition, we found that RING finger domain and BRCT domain of BRCA1 could physically interact with p53 in NSCs.
The cross talk between BRCA1 RING finger domain and p53 was responsible for p53 ubiquitination and degradation.
Our findings indicate that modification with BRCA1 could enhance the efficacy of NSCs transplantation in ischemic stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Pengfei& Shi, Xiaolei& Zhang, Xiaohao& Liu, Qian& Xie, Yi& Hong, Ye…[et al.]. 2019. Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Pengfei…[et al.]. Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Pengfei& Shi, Xiaolei& Zhang, Xiaohao& Liu, Qian& Xie, Yi& Hong, Ye…[et al.]. Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر