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Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c
المؤلفون المشاركون
Yang, Qin-He
Zhang, Yu-Pei
Deng, Yuanjun
Chen, Runsen
Tang, Kairui
Zheng, Chuiyang
Nie, Huan
Pan, Maoxing
Xie, Jiqian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, and its incidence is increasing annually, but there is currently no specific drug for treating NAFLD.
Shenling Baizhu powder (SL) is a safe herbal compound commonly used in clinical practice.
Our previous research has shown that SL has the effect of preventing NAFLD, but its specific mechanism has not been determined.
In this study, the potential mechanism of SL on NAFLD was explored by in vivo experiments.
Methods.
Wistar rats fed a choline-deficient amino acid-defined diet (CDAA) were treated with SL for 8 weeks.
Then, serum samples were collected to obtain biochemical indicators; adipose tissue and liver samples were collected for pathological detection; a moorFLPI-2 blood flow imager was used to measure liver microcirculation blood flow, and a rat cytokine array was used to screen potential target proteins.
The expression of liver adiponectin/SREBP-1c pathway-related proteins was determined by Western blotting.
Results.
SL effectively reduced the liver wet weight, as well as the levels of total cholesterol (TC) and triglyceride (TG) in the liver, and ameliorated liver injury in CDAA-fed rats.
Pathological examinations showed that SL markedly reduced liver lipid droplets and improved liver lipid accumulation.
In addition, the detection of liver blood flow showed that SL increased liver microcirculation in CDAA-fed rats.
Through the cytokine array, a differentially expressed cytokine, namely, adiponectin, was screened in the liver.
Western blotting assays showed that SL increased the expression of adiponectin and phosphoacetyl-CoA Carboxylase (p-ACC) in the liver and decreased the expression of steroid regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS).
Conclusion.
These results suggest that SL can increase the levels of adiponectin in the liver and serum and can inhibit the expression of SREBP-1c, thereby regulating systemic lipid metabolism and reducing liver lipid accumulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Kairui& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Pan, Maoxing& Chen, Runsen…[et al.]. 2020. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Kairui…[et al.]. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Kairui& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Pan, Maoxing& Chen, Runsen…[et al.]. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206110
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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