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Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c
Joint Authors
Yang, Qin-He
Zhang, Yu-Pei
Deng, Yuanjun
Chen, Runsen
Tang, Kairui
Zheng, Chuiyang
Nie, Huan
Pan, Maoxing
Xie, Jiqian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, and its incidence is increasing annually, but there is currently no specific drug for treating NAFLD.
Shenling Baizhu powder (SL) is a safe herbal compound commonly used in clinical practice.
Our previous research has shown that SL has the effect of preventing NAFLD, but its specific mechanism has not been determined.
In this study, the potential mechanism of SL on NAFLD was explored by in vivo experiments.
Methods.
Wistar rats fed a choline-deficient amino acid-defined diet (CDAA) were treated with SL for 8 weeks.
Then, serum samples were collected to obtain biochemical indicators; adipose tissue and liver samples were collected for pathological detection; a moorFLPI-2 blood flow imager was used to measure liver microcirculation blood flow, and a rat cytokine array was used to screen potential target proteins.
The expression of liver adiponectin/SREBP-1c pathway-related proteins was determined by Western blotting.
Results.
SL effectively reduced the liver wet weight, as well as the levels of total cholesterol (TC) and triglyceride (TG) in the liver, and ameliorated liver injury in CDAA-fed rats.
Pathological examinations showed that SL markedly reduced liver lipid droplets and improved liver lipid accumulation.
In addition, the detection of liver blood flow showed that SL increased liver microcirculation in CDAA-fed rats.
Through the cytokine array, a differentially expressed cytokine, namely, adiponectin, was screened in the liver.
Western blotting assays showed that SL increased the expression of adiponectin and phosphoacetyl-CoA Carboxylase (p-ACC) in the liver and decreased the expression of steroid regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS).
Conclusion.
These results suggest that SL can increase the levels of adiponectin in the liver and serum and can inhibit the expression of SREBP-1c, thereby regulating systemic lipid metabolism and reducing liver lipid accumulation.
American Psychological Association (APA)
Tang, Kairui& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Pan, Maoxing& Chen, Runsen…[et al.]. 2020. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
Modern Language Association (MLA)
Tang, Kairui…[et al.]. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
American Medical Association (AMA)
Tang, Kairui& Deng, Yuanjun& Zheng, Chuiyang& Nie, Huan& Pan, Maoxing& Chen, Runsen…[et al.]. Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1206110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206110