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The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?
المؤلفون المشاركون
Khan, Tanzila
Scott, Kieran F.
Becker, Therese M.
Lock, John
Nimir, Mohammed
Ma, Yafeng
de Souza, Paul
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment.
However, the development of drug resistance is a significant limitation on the effectiveness of both first-line and more recently developed second-line ADTs.
There is a need then to study AR signaling within the context of other oncogenic signaling pathways that likely mediate this resistance.
This review focuses on interactions between AR signaling, the well-known phosphatidylinositol-3-kinase/AKT pathway, and an emerging mediator of these pathways, the Hippo/YAP1 axis in metastatic castrate-resistant PCa, and their involvement in the regulation of epithelial-mesenchymal transition (EMT), a feature of disease progression and ADT resistance.
Analysis of these pathways in circulating tumor cells (CTCs) may provide an opportunity to evaluate their utility as biomarkers and address their importance in the development of resistance to current ADT with potential to guide future therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khan, Tanzila& Scott, Kieran F.& Becker, Therese M.& Lock, John& Nimir, Mohammed& Ma, Yafeng…[et al.]. 2020. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khan, Tanzila…[et al.]. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khan, Tanzila& Scott, Kieran F.& Becker, Therese M.& Lock, John& Nimir, Mohammed& Ma, Yafeng…[et al.]. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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