The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?
Joint Authors
Khan, Tanzila
Scott, Kieran F.
Becker, Therese M.
Lock, John
Nimir, Mohammed
Ma, Yafeng
de Souza, Paul
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment.
However, the development of drug resistance is a significant limitation on the effectiveness of both first-line and more recently developed second-line ADTs.
There is a need then to study AR signaling within the context of other oncogenic signaling pathways that likely mediate this resistance.
This review focuses on interactions between AR signaling, the well-known phosphatidylinositol-3-kinase/AKT pathway, and an emerging mediator of these pathways, the Hippo/YAP1 axis in metastatic castrate-resistant PCa, and their involvement in the regulation of epithelial-mesenchymal transition (EMT), a feature of disease progression and ADT resistance.
Analysis of these pathways in circulating tumor cells (CTCs) may provide an opportunity to evaluate their utility as biomarkers and address their importance in the development of resistance to current ADT with potential to guide future therapies.
American Psychological Association (APA)
Khan, Tanzila& Scott, Kieran F.& Becker, Therese M.& Lock, John& Nimir, Mohammed& Ma, Yafeng…[et al.]. 2020. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
Modern Language Association (MLA)
Khan, Tanzila…[et al.]. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
American Medical Association (AMA)
Khan, Tanzila& Scott, Kieran F.& Becker, Therese M.& Lock, John& Nimir, Mohammed& Ma, Yafeng…[et al.]. The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?. Prostate Cancer. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1206360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206360