Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis
المؤلفون المشاركون
Ghosh, Abhinaba
Das, Saibal
Behera, Sapan Kumar
Ramakrishnan, Kirubakaran
Selvarajan, Sandhiya
Kandasamy, Preeti
Nair, N Sreekumaran
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
To evaluate the effects of atomoxetine on complex attention and other neurocognitive domains in idiopathic Parkinson’s disease (PD).
Methods.
Interventional trials reporting changes in complex attention and other neurocognitive functions (Diagnostic and Statistical Manual of Mental Disorders-5) following administration of atomoxetine for at least 8 weeks in adults with idiopathic PD were included.
Effect sizes (Cohen’s d), the standardized mean difference in the scores of each cognitive domain, were compared using a random-effects model (MetaXL version 5.3).
Results.
Three studies were included in the final analysis.
For a change in complex attention in PD with mild cognitive impairment (MCI), the estimated effect size was small and nonsignificant (0.16 (95% CI: −0.09, 0.42), n = 42).
For changes in executive function, perceptual-motor function, language, social cognition, and learning and memory, the estimated effect sizes were small and medium, but nonsignificant.
A deteriorative trend in executive function was observed after atomoxetine treatment in PD with MCI.
For a change in global cognitive function in PD without MCI, the estimated effect size was large and significant.
Conclusion.
In idiopathic PD with MCI, atomoxetine does not improve complex attention.
Also, a deteriorative trend in the executive function was noted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghosh, Abhinaba& Das, Saibal& Behera, Sapan Kumar& Ramakrishnan, Kirubakaran& Selvarajan, Sandhiya& Kandasamy, Preeti…[et al.]. 2020. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghosh, Abhinaba…[et al.]. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghosh, Abhinaba& Das, Saibal& Behera, Sapan Kumar& Ramakrishnan, Kirubakaran& Selvarajan, Sandhiya& Kandasamy, Preeti…[et al.]. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر