Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis
Joint Authors
Ghosh, Abhinaba
Das, Saibal
Behera, Sapan Kumar
Ramakrishnan, Kirubakaran
Selvarajan, Sandhiya
Kandasamy, Preeti
Nair, N Sreekumaran
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To evaluate the effects of atomoxetine on complex attention and other neurocognitive domains in idiopathic Parkinson’s disease (PD).
Methods.
Interventional trials reporting changes in complex attention and other neurocognitive functions (Diagnostic and Statistical Manual of Mental Disorders-5) following administration of atomoxetine for at least 8 weeks in adults with idiopathic PD were included.
Effect sizes (Cohen’s d), the standardized mean difference in the scores of each cognitive domain, were compared using a random-effects model (MetaXL version 5.3).
Results.
Three studies were included in the final analysis.
For a change in complex attention in PD with mild cognitive impairment (MCI), the estimated effect size was small and nonsignificant (0.16 (95% CI: −0.09, 0.42), n = 42).
For changes in executive function, perceptual-motor function, language, social cognition, and learning and memory, the estimated effect sizes were small and medium, but nonsignificant.
A deteriorative trend in executive function was observed after atomoxetine treatment in PD with MCI.
For a change in global cognitive function in PD without MCI, the estimated effect size was large and significant.
Conclusion.
In idiopathic PD with MCI, atomoxetine does not improve complex attention.
Also, a deteriorative trend in the executive function was noted.
American Psychological Association (APA)
Ghosh, Abhinaba& Das, Saibal& Behera, Sapan Kumar& Ramakrishnan, Kirubakaran& Selvarajan, Sandhiya& Kandasamy, Preeti…[et al.]. 2020. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
Modern Language Association (MLA)
Ghosh, Abhinaba…[et al.]. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
American Medical Association (AMA)
Ghosh, Abhinaba& Das, Saibal& Behera, Sapan Kumar& Ramakrishnan, Kirubakaran& Selvarajan, Sandhiya& Kandasamy, Preeti…[et al.]. Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson’s Disease Patients with Cognitive Deficits: A Meta-Analysis. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1206457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206457