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Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer
المؤلفون المشاركون
Wu, Jiande
Hicks, Chindo
Mamidi, Tarun Karthik Kumar
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA.
Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of germline genetic susceptibility variants and somatic mutations acquired during tumor formation.
Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis.
However, the possible oncogenic interactions and cooperation between germline and somatic variation and their role in aggressive PCa remain largely unexplored.
Here we investigated the possible oncogenic interactions and cooperation between genes containing germline variation from genome-wide association studies (GWAS) and genes containing somatic mutations from tumor genomes of 305 men with aggressive tumors and 52 control samples from The Cancer Genome Atlas (TCGA).
Network and pathway analysis were performed to identify molecular networks and biological pathways enriched for germline and somatic mutations.
The analysis revealed 90 functionally related genes containing both germline and somatic mutations.
Transcriptome analysis revealed a 61-gene signature containing both germline and somatic mutations.
Network analysis revealed molecular networks of functionally related genes and biological pathways including P53, STAT3, NKX3-1, KLK3, and Androgen receptor signaling pathways enriched for germline and somatic mutations.
The results show that integrative analysis is a powerful approach to uncovering the possible oncogenic interactions and cooperation between germline and somatic mutations and understanding the broader biological context in which they operate in aggressive PCa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mamidi, Tarun Karthik Kumar& Wu, Jiande& Hicks, Chindo. 2019. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mamidi, Tarun Karthik Kumar…[et al.]. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mamidi, Tarun Karthik Kumar& Wu, Jiande& Hicks, Chindo. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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