Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer
Joint Authors
Wu, Jiande
Hicks, Chindo
Mamidi, Tarun Karthik Kumar
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA.
Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of germline genetic susceptibility variants and somatic mutations acquired during tumor formation.
Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis.
However, the possible oncogenic interactions and cooperation between germline and somatic variation and their role in aggressive PCa remain largely unexplored.
Here we investigated the possible oncogenic interactions and cooperation between genes containing germline variation from genome-wide association studies (GWAS) and genes containing somatic mutations from tumor genomes of 305 men with aggressive tumors and 52 control samples from The Cancer Genome Atlas (TCGA).
Network and pathway analysis were performed to identify molecular networks and biological pathways enriched for germline and somatic mutations.
The analysis revealed 90 functionally related genes containing both germline and somatic mutations.
Transcriptome analysis revealed a 61-gene signature containing both germline and somatic mutations.
Network analysis revealed molecular networks of functionally related genes and biological pathways including P53, STAT3, NKX3-1, KLK3, and Androgen receptor signaling pathways enriched for germline and somatic mutations.
The results show that integrative analysis is a powerful approach to uncovering the possible oncogenic interactions and cooperation between germline and somatic mutations and understanding the broader biological context in which they operate in aggressive PCa.
American Psychological Association (APA)
Mamidi, Tarun Karthik Kumar& Wu, Jiande& Hicks, Chindo. 2019. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
Modern Language Association (MLA)
Mamidi, Tarun Karthik Kumar…[et al.]. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
American Medical Association (AMA)
Mamidi, Tarun Karthik Kumar& Wu, Jiande& Hicks, Chindo. Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer. Prostate Cancer. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1206793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206793