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Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress
المؤلفون المشاركون
Rostami, Zahra
Ghasemi, Sahar
Farzadmanesh, Hamed
Safari, Manouchehr
Ghanbari, Ali
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries.
We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity.
Materials and Methods.
Twenty-eight Wistar rats of either sex and 180–220 grams were divided into 4 groups as sham, neuropathy, neuropathy + single bout exercise, and neuropathy + 2 weeks of exercise.
Trigeminal neuropathy was carried out through chronic constriction injury (CCI) of infraorbital nerve.
Protocols of exercise were included a single bout session (45 minutes) and a 2-week (45 minutes/day/6 days a week) swimming exercise.
Mechanical allodynia was detected using Von Frey filaments.
The activity of the serum antioxidant enzymes glutathione peroxidase and superoxides dismutase was assayed using ELISA kits.
Results.
We found that CCI significantly reduced facial pain threshold in both sexes (P<0.05).
Both swimming exercise protocols significantly reduced mechanical allodynia in female rats compared to the sham group; however, only 2 weeks of exercise were significantly effective in male rats.
The activity of antioxidant enzyme glutathione peroxidase significantly (P<0.05) decreased following CCI in female rats against that in the sham group and 2-week exercise significantly (P<0.05) increased it toward the control level.
The levels of glutathione peroxidase in male rats and superoxidase dismutase in both sexes were not significantly different compared to their sham groups.
Conclusion.
Swimming exercise alleviates trigeminal neuropathic pain in both sexes.
Oxidative stress as a possible mechanism was involved in the effect of exercise on female rat trigeminal neuropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rostami, Zahra& Ghasemi, Sahar& Farzadmanesh, Hamed& Safari, Manouchehr& Ghanbari, Ali. 2020. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rostami, Zahra…[et al.]. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rostami, Zahra& Ghasemi, Sahar& Farzadmanesh, Hamed& Safari, Manouchehr& Ghanbari, Ali. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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