Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress
Joint Authors
Rostami, Zahra
Ghasemi, Sahar
Farzadmanesh, Hamed
Safari, Manouchehr
Ghanbari, Ali
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
Orofacial chronic neuropathic pain commonly occurs following trigeminal nerve injuries.
We investigated whether swimming exercise can reduce trigeminal neuropathic pain through improving antioxidant capacity.
Materials and Methods.
Twenty-eight Wistar rats of either sex and 180–220 grams were divided into 4 groups as sham, neuropathy, neuropathy + single bout exercise, and neuropathy + 2 weeks of exercise.
Trigeminal neuropathy was carried out through chronic constriction injury (CCI) of infraorbital nerve.
Protocols of exercise were included a single bout session (45 minutes) and a 2-week (45 minutes/day/6 days a week) swimming exercise.
Mechanical allodynia was detected using Von Frey filaments.
The activity of the serum antioxidant enzymes glutathione peroxidase and superoxides dismutase was assayed using ELISA kits.
Results.
We found that CCI significantly reduced facial pain threshold in both sexes (P<0.05).
Both swimming exercise protocols significantly reduced mechanical allodynia in female rats compared to the sham group; however, only 2 weeks of exercise were significantly effective in male rats.
The activity of antioxidant enzyme glutathione peroxidase significantly (P<0.05) decreased following CCI in female rats against that in the sham group and 2-week exercise significantly (P<0.05) increased it toward the control level.
The levels of glutathione peroxidase in male rats and superoxidase dismutase in both sexes were not significantly different compared to their sham groups.
Conclusion.
Swimming exercise alleviates trigeminal neuropathic pain in both sexes.
Oxidative stress as a possible mechanism was involved in the effect of exercise on female rat trigeminal neuropathy.
American Psychological Association (APA)
Rostami, Zahra& Ghasemi, Sahar& Farzadmanesh, Hamed& Safari, Manouchehr& Ghanbari, Ali. 2020. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
Modern Language Association (MLA)
Rostami, Zahra…[et al.]. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
American Medical Association (AMA)
Rostami, Zahra& Ghasemi, Sahar& Farzadmanesh, Hamed& Safari, Manouchehr& Ghanbari, Ali. Sex Difference in Trigeminal Neuropathic Pain Response to Exercise: Role of Oxidative Stress. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1206803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206803