Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown
المؤلفون المشاركون
Thao, Dang Thi Phuong
Truong, Huynh Kim Thoa
Huynh, Man Anh
Vuu, My Dung
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders.
There have been numerous in vitro and in vivo models developed to study mechanisms of PD and screen potential drug.
Recently, dUCH-knockdown Drosophila model has been established and showed potential for screening antioxidants for PD treatment.
The dUCH-knockdown Drosophila model of PD mimics most of main PD pathologies such as dopaminergic neurons degeneration, locomotor dysfunction, and shortage of dopamine in the brain.
Common purslane (Portulaca oleracea L.) is a nutritious vegetable containing a variety of antioxidants, levodopa, and dopamine, a neurotransmitter closely related to PD.
Purslane has been reported to exert neuroprotective effects against several neurotoxins including rotenone and 6-OHDA in PD models.
However, the recent data have not provided sufficient evidence for using purslane to treat PD or decelerate disease progression.
Therefore, in this study, we utilized dUCH-knockdown fly to evaluate the capacity of purslane extracts for PD treatment.
The results showed that purslane extracts improved locomotor ability in the larval stage and decelerated disease progression in the adult stage.
Additionally, purslane extracts also reduced dopaminergic neuron degeneration.
Taken together, our data strongly demonstrated that purslane extracts effectively rescued PD-like phenotypes in the fly model.
This result contributed a foundation for further study on the application of purslane in PD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Truong, Huynh Kim Thoa& Huynh, Man Anh& Vuu, My Dung& Thao, Dang Thi Phuong. 2019. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Truong, Huynh Kim Thoa…[et al.]. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Truong, Huynh Kim Thoa& Huynh, Man Anh& Vuu, My Dung& Thao, Dang Thi Phuong. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر