Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown
Joint Authors
Thao, Dang Thi Phuong
Truong, Huynh Kim Thoa
Huynh, Man Anh
Vuu, My Dung
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Parkinson’s disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders.
There have been numerous in vitro and in vivo models developed to study mechanisms of PD and screen potential drug.
Recently, dUCH-knockdown Drosophila model has been established and showed potential for screening antioxidants for PD treatment.
The dUCH-knockdown Drosophila model of PD mimics most of main PD pathologies such as dopaminergic neurons degeneration, locomotor dysfunction, and shortage of dopamine in the brain.
Common purslane (Portulaca oleracea L.) is a nutritious vegetable containing a variety of antioxidants, levodopa, and dopamine, a neurotransmitter closely related to PD.
Purslane has been reported to exert neuroprotective effects against several neurotoxins including rotenone and 6-OHDA in PD models.
However, the recent data have not provided sufficient evidence for using purslane to treat PD or decelerate disease progression.
Therefore, in this study, we utilized dUCH-knockdown fly to evaluate the capacity of purslane extracts for PD treatment.
The results showed that purslane extracts improved locomotor ability in the larval stage and decelerated disease progression in the adult stage.
Additionally, purslane extracts also reduced dopaminergic neuron degeneration.
Taken together, our data strongly demonstrated that purslane extracts effectively rescued PD-like phenotypes in the fly model.
This result contributed a foundation for further study on the application of purslane in PD treatment.
American Psychological Association (APA)
Truong, Huynh Kim Thoa& Huynh, Man Anh& Vuu, My Dung& Thao, Dang Thi Phuong. 2019. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
Modern Language Association (MLA)
Truong, Huynh Kim Thoa…[et al.]. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
American Medical Association (AMA)
Truong, Huynh Kim Thoa& Huynh, Man Anh& Vuu, My Dung& Thao, Dang Thi Phuong. Evaluating the Potential of Portulaca oleracea L. for Parkinson’s Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1206842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1206842