Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic
المؤلفون المشاركون
Park, Jung-Ho
Park, Jae-Hyung
Son, Jo-Young
Lim, Jae-Seong
Park, Jae-Hyeong
Kim, Myeong-Shin
Oh, Jun-suk
Yoon, Hyun-Wu
Ju, Jin-Sook
Ahn, Dong-Kuk
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Mannitol has recently been reported to be effective in enhancing the antinociceptive efficacy of lidocaine.
No single study to date, however, has compared diphenhydramine with and without mannitol for nociceptive processing as an alternative local anesthetic.
In this study, we examined the antinociceptive efficacy enhancements of diphenhydramine when combined with mannitol.
Male Sprague-Dawley rats weighing 230–260 g were used in a hot plate test to evaluate the antinociceptive effects of diphenhydramine.
All chemicals were dissolved in isotonic normal saline and administered subcutaneously into the plantar surface of the right hind paw at 10 min before the hot plate test.
A subcutaneous injection of 0.5% or 1% diphenhydramine produced significant inhibition of the withdrawal latency time compared with the vehicle treatment.
Antinociceptive effects appeared 10 min after the diphenhydramine injections and persisted for over 30 min.
The antinociceptive effects of 1% diphenhydramine were not statistically different from those of 1% lidocaine.
Although a subcutaneous injection of a 0.5 M mannitol solution alone did not affect the withdrawal latency time, 1% diphenhydramine with 0.5 M mannitol significantly enhanced antinociception.
A subcutaneous injection of 1% diphenhydramine with epinephrine (1 : 100,000) solution did not increase the antinociceptive effect of the diphenhydramine.
These results suggest that diphenhydramine with mannitol can be used as an alternative local anesthetic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Son, Jo-Young& Lim, Jae-Seong& Park, Jae-Hyung& Park, Jae-Hyeong& Kim, Myeong-Shin& Park, Jung-Ho…[et al.]. 2020. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Son, Jo-Young…[et al.]. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1207005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Son, Jo-Young& Lim, Jae-Seong& Park, Jae-Hyung& Park, Jae-Hyeong& Kim, Myeong-Shin& Park, Jung-Ho…[et al.]. Mannitol Enhances the Antinociceptive Effects of Diphenhydramine as an Alternative Local Anesthetic. Pain Research and Management. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1207005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر