Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis
المؤلفون المشاركون
Nabil Ahmed, Ahmed
Zahran, Faten
Shiha, Gamal
Lotfy, Ahmed
Soliman, Reham
Hassan, Ayman A.
Ali, Islam S.
Gad, Doaa F.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-03
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Liver fibrosis is the excessive extracellular matrix accumulation of proteins, such as collagen, which follows the chronic liver diseases.
Advanced liver fibrosis leads to cirrhosis and liver failure.
Nilotinib is a second-generation tyrosine kinase inhibitor, which showed antifibrotic efficacy.
Stem cell therapy still has some limitations such as oncogenesis, unexpected differentiation, and ethical consideration.
Stem cells secrete cytokines and growth factors that showed paracrine-mediated antifibrotic and anti-inflammatory effects in vivo and in vitro.
Thus, stem cell-conditioned medium (SC-CM), which contains the secretory proteins of stem cells, may have an antifibrotic role.
This study was carried out to examine the antifibrotic effect of Nilotinib and stem cell exosomes on CCl4-induced liver fibrosis in rats.
Male Wistar rats were injected intraperitoneally with CCl4 twice a week for 9 weeks and given daily treatments of Nilotinib (20 mg/kg), stem cell exosomes (0.5 ml/rat), and the combination treatment of Nilotinib and stem cell exosomes during the last 5 weeks of CCl4 intoxication.
Liver fibrosis and also antifibrotic efficacy of the treatments were estimated with liver function tests, oxidative stress parameters, apoptotic parameters, histopathological examination, and hydroxyproline contents.
Results showed that the combination of Nilotinib and stem cell-conditioned media had more antifibrotic effects than each one alone (P value < 0.001).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shiha, Gamal& Nabil Ahmed, Ahmed& Lotfy, Ahmed& Soliman, Reham& Hassan, Ayman A.& Ali, Islam S.…[et al.]. 2020. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shiha, Gamal…[et al.]. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shiha, Gamal& Nabil Ahmed, Ahmed& Lotfy, Ahmed& Soliman, Reham& Hassan, Ayman A.& Ali, Islam S.…[et al.]. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر