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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis
Joint Authors
Nabil Ahmed, Ahmed
Zahran, Faten
Shiha, Gamal
Lotfy, Ahmed
Soliman, Reham
Hassan, Ayman A.
Ali, Islam S.
Gad, Doaa F.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-03
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Liver fibrosis is the excessive extracellular matrix accumulation of proteins, such as collagen, which follows the chronic liver diseases.
Advanced liver fibrosis leads to cirrhosis and liver failure.
Nilotinib is a second-generation tyrosine kinase inhibitor, which showed antifibrotic efficacy.
Stem cell therapy still has some limitations such as oncogenesis, unexpected differentiation, and ethical consideration.
Stem cells secrete cytokines and growth factors that showed paracrine-mediated antifibrotic and anti-inflammatory effects in vivo and in vitro.
Thus, stem cell-conditioned medium (SC-CM), which contains the secretory proteins of stem cells, may have an antifibrotic role.
This study was carried out to examine the antifibrotic effect of Nilotinib and stem cell exosomes on CCl4-induced liver fibrosis in rats.
Male Wistar rats were injected intraperitoneally with CCl4 twice a week for 9 weeks and given daily treatments of Nilotinib (20 mg/kg), stem cell exosomes (0.5 ml/rat), and the combination treatment of Nilotinib and stem cell exosomes during the last 5 weeks of CCl4 intoxication.
Liver fibrosis and also antifibrotic efficacy of the treatments were estimated with liver function tests, oxidative stress parameters, apoptotic parameters, histopathological examination, and hydroxyproline contents.
Results showed that the combination of Nilotinib and stem cell-conditioned media had more antifibrotic effects than each one alone (P value < 0.001).
American Psychological Association (APA)
Shiha, Gamal& Nabil Ahmed, Ahmed& Lotfy, Ahmed& Soliman, Reham& Hassan, Ayman A.& Ali, Islam S.…[et al.]. 2020. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
Modern Language Association (MLA)
Shiha, Gamal…[et al.]. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
American Medical Association (AMA)
Shiha, Gamal& Nabil Ahmed, Ahmed& Lotfy, Ahmed& Soliman, Reham& Hassan, Ayman A.& Ali, Islam S.…[et al.]. Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1207838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1207838