Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier
المؤلفون المشاركون
Mao, Pu
Qiu, Haibo
Meng, Shan-shan
Xu, Xiu-Ping
Huang, Yong-bo
Li, Yi-min
Pan, Chun
Yang, Yi
Li, Jin-ze
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-30
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Mesenchymal stem cells (MSCs) may improve the treatment of acute respiratory distress syndrome (ARDS).
However, few studies have investigated the effects of mechanically stretched -MSCs (MS-MSCs) in in vitro models of ARDS.
The aim of this study was to evaluate the potential therapeutic effects of MS-MSCs on pulmonary microvascular endothelium barrier injuries induced by LPS.
We introduced a cocultured model of pulmonary microvascular endothelial cell (EC) and MSC medium obtained from MSCs with or without mechanical stretch.
We found that Wright-Giemsa staining revealed that MSC morphology changed significantly and cell plasma shrank separately after mechanical stretch.
Cell proliferation of the MS-MSC groups was much lower than the untreated MSC group; expression of cell surface markers did not change significantly.
Compared to the medium from untreated MSCs, inflammatory factors elevated statistically in the medium from MS-MSCs.
Moreover, the paracellular permeability of endothelial cells treated with LPS was restored with a medium from MS-MSCs, while LPS-induced EC apoptosis decreased.
In addition, protective effects on the remodeling of intercellular junctions were observed when compared to LPS-treated endothelial cells.
These data demonstrated that the MS-MSC groups had potential therapeutic effects on the LPS-treated ECs; these results might be useful in the treatment of ARDS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jin-ze& Meng, Shan-shan& Xu, Xiu-Ping& Huang, Yong-bo& Mao, Pu& Li, Yi-min…[et al.]. 2020. Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier. Stem Cells International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1208003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jin-ze…[et al.]. Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier. Stem Cells International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1208003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jin-ze& Meng, Shan-shan& Xu, Xiu-Ping& Huang, Yong-bo& Mao, Pu& Li, Yi-min…[et al.]. Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1208003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر