Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice

المؤلفون المشاركون

Liu, Zhiyuan
Xiao, Shune
Deng, Yurong
Mo, Xiaojin
Wang, Dali
Deng, Chengliang
Wei, Zairong

المصدر

Stem Cells International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-06-13

دولة النشر

مصر

عدد الصفحات

11

الملخص EN

Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss.

However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare.

ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines.

Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth.

Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy.

In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice.

ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction.

ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth.

These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xiao, Shune& Deng, Yurong& Mo, Xiaojin& Liu, Zhiyuan& Wang, Dali& Deng, Chengliang…[et al.]. 2020. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208092

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xiao, Shune…[et al.]. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1208092

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xiao, Shune& Deng, Yurong& Mo, Xiaojin& Liu, Zhiyuan& Wang, Dali& Deng, Chengliang…[et al.]. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208092

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1208092