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Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice
Joint Authors
Liu, Zhiyuan
Xiao, Shune
Deng, Yurong
Mo, Xiaojin
Wang, Dali
Deng, Chengliang
Wei, Zairong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-13
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss.
However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare.
ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines.
Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth.
Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy.
In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice.
ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction.
ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth.
These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.
American Psychological Association (APA)
Xiao, Shune& Deng, Yurong& Mo, Xiaojin& Liu, Zhiyuan& Wang, Dali& Deng, Chengliang…[et al.]. 2020. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208092
Modern Language Association (MLA)
Xiao, Shune…[et al.]. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1208092
American Medical Association (AMA)
Xiao, Shune& Deng, Yurong& Mo, Xiaojin& Liu, Zhiyuan& Wang, Dali& Deng, Chengliang…[et al.]. Promotion of Hair Growth by Conditioned Medium from Extracellular MatrixStromal Vascular Fraction Gel in C57BL6 Mice. Stem Cells International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1208092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1208092