Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells

المؤلفون المشاركون

Tang, Min
Chen, Rui
Wang, Hao
Sun, Guowei
Yin, Fan
Liang, Beibei
Yang, Yang
Sharen, Gaowa
Wei, Huafeng
Zhou, Xuyu
Huang, Gang
Zhao, Jian

المصدر

Stem Cells International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-02-17

دولة النشر

مصر

عدد الصفحات

13

الملخص EN

Obesity is a major risk factor for many chronic diseases, including diabetes, fatty livers, and cancer.

Expansion of the adipose mass has been shown to be related to adipogenic differentiation of adipose-derived mesenchymal stem cells (ASCs).

However, the underlying mechanism of this effect has yet to be elucidated.

We found that osteopontin (OPN) is downregulated in ASCs and adipose tissues of obese mice and overweight human beings because of methylation on its promoter, indicating that OPN may affect the development of obesity.

Silencing of OPN in wild-type ASCs promotes adipogenic differentiation, while reexpression of OPN reduced adipogenic differentiation in OPN−/− ASCs.

The role of extracellular OPN in ASC differentiation was further demonstrated by supplementation and neutralization of OPN.

Additionally, OPN suppresses adipogenic differentiation in ASCs through the C/EBP pathways.

Consistent with these in vitro results, by intravenous injection of OPN-expressing adenovirus to the mice, we found OPN can delay the development of obesity and improve insulin sensitivity.

Therefore, our study demonstrates an important role of OPN in regulating the development of obesity, indicating OPN might be a novel target to attenuate obesity and its complications.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tang, Min& Chen, Rui& Wang, Hao& Sun, Guowei& Yin, Fan& Liang, Beibei…[et al.]. 2019. Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells. Stem Cells International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1208146

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tang, Min…[et al.]. Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells. Stem Cells International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1208146

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tang, Min& Chen, Rui& Wang, Hao& Sun, Guowei& Yin, Fan& Liang, Beibei…[et al.]. Obesity-Induced Methylation of Osteopontin Contributes to Adipogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1208146

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1208146