Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction

المؤلفون المشاركون

Tian, Zhigang
Meng, Deping
Qin, Yuhong
Lu, Nan
Fang, Keke
Hu, Yuan
Zhang, Cai

المصدر

Stem Cells International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-07-01

دولة النشر

مصر

عدد الصفحات

15

الملخص EN

It has been reported that the adult liver contains hematopoietic stem and progenitor cells (HSPCs), which are associated with long-term hematopoietic reconstitution activity.

Hepatic hematopoiesis plays an important role in the generation of cells involved in liver diseases.

However, how the progenitors differentiate into functional myeloid cells and lymphocytes in the liver microenvironment remains unknown.

In the present study, HSPC transplantation experiments were used to confirm that adult murine liver HSPCs differentiate into both myeloid cells and lymphocytes (preferentially T cells) compared with bone marrow HSPCs.

Using a coculture system comprised of kupffer cells and HSPCs, we found that kupffer cells promote adult liver HSPCs to primarily generate T cells and B cells.

We then demonstrated that kupffer cells can also promote HSPC expansion.

A blockade of intercellular cell adhesion molecule-1 (ICAM-1) in a liver HSPC and kupffer cell coculture system impaired the adhesion, expansion, and differentiation of HSPCs.

These results suggest a critical role of kupffer cells in the maintenance and promotion of adult mouse liver hematopoiesis.

These findings provide important insight into understanding liver extramedullary hematopoiesis and its significance, particularly under the state of some liver diseases, such as hepatitis, nonalcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Meng, Deping& Qin, Yuhong& Fang, Keke& Hu, Yuan& Tian, Zhigang& Zhang, Cai…[et al.]. 2019. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fang, Keke…[et al.]. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Meng, Deping& Qin, Yuhong& Fang, Keke& Hu, Yuan& Tian, Zhigang& Zhang, Cai…[et al.]. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1208902