Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction

Joint Authors

Tian, Zhigang
Meng, Deping
Qin, Yuhong
Lu, Nan
Fang, Keke
Hu, Yuan
Zhang, Cai

Source

Stem Cells International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-07-01

Country of Publication

Egypt

No. of Pages

15

Abstract EN

It has been reported that the adult liver contains hematopoietic stem and progenitor cells (HSPCs), which are associated with long-term hematopoietic reconstitution activity.

Hepatic hematopoiesis plays an important role in the generation of cells involved in liver diseases.

However, how the progenitors differentiate into functional myeloid cells and lymphocytes in the liver microenvironment remains unknown.

In the present study, HSPC transplantation experiments were used to confirm that adult murine liver HSPCs differentiate into both myeloid cells and lymphocytes (preferentially T cells) compared with bone marrow HSPCs.

Using a coculture system comprised of kupffer cells and HSPCs, we found that kupffer cells promote adult liver HSPCs to primarily generate T cells and B cells.

We then demonstrated that kupffer cells can also promote HSPC expansion.

A blockade of intercellular cell adhesion molecule-1 (ICAM-1) in a liver HSPC and kupffer cell coculture system impaired the adhesion, expansion, and differentiation of HSPCs.

These results suggest a critical role of kupffer cells in the maintenance and promotion of adult mouse liver hematopoiesis.

These findings provide important insight into understanding liver extramedullary hematopoiesis and its significance, particularly under the state of some liver diseases, such as hepatitis, nonalcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC).

American Psychological Association (APA)

Meng, Deping& Qin, Yuhong& Fang, Keke& Hu, Yuan& Tian, Zhigang& Zhang, Cai…[et al.]. 2019. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

Modern Language Association (MLA)

Fang, Keke…[et al.]. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

American Medical Association (AMA)

Meng, Deping& Qin, Yuhong& Fang, Keke& Hu, Yuan& Tian, Zhigang& Zhang, Cai…[et al.]. Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1208902

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1208902