Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice
المؤلفون المشاركون
Sawa, Yoshiki
Miyagawa, Shigeru
Kimura, Atsuomi
Momozane, Toru
Fukui, Eriko
Funaki, Soichiro
Okumura, Meinoshin
Shintani, Yasushi
Kimura, Kenji
Chijimatsu, Ryota
Kanzaki, Ryu
Kanou, Takashi
Ose, Naoko
Minami, Masato
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-10
دولة النشر
مصر
عدد الصفحات
14
الملخص EN
Chronic obstructive pulmonary disease is a leading cause of mortality globally, with no effective therapy yet established.
Adipose tissue-derived stem cells (ADSCs) are useful for ameliorating lung injury in animal models.
However, whether ADSCs differentiate into functional cells remains uncertain, and no study has reported on the mechanism by which ADSCs improve lung functionality.
Thus, in this study, we examined whether ADSCs differentiate into lung alveolar cells and are able to ameliorate lung injury caused by elastase-induced emphysema in model mice.
Here, we induced ADSCs to differentiate into type 2 alveolar epithelial cells in vitro.
We demonstrated that ADSCs can differentiate into type 2 alveolar epithelial cells in an elastase-induced emphysematous lung and that ADSCs improve pulmonary function of emphysema model mice, as determined with spirometry and 129Xe MRI.
These data revealed a novel function for ADSCs in promoting repair of the damaged lung by direct differentiation into alveolar epithelial cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fukui, Eriko& Funaki, Soichiro& Kimura, Kenji& Momozane, Toru& Kimura, Atsuomi& Chijimatsu, Ryota…[et al.]. 2019. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fukui, Eriko…[et al.]. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fukui, Eriko& Funaki, Soichiro& Kimura, Kenji& Momozane, Toru& Kimura, Atsuomi& Chijimatsu, Ryota…[et al.]. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر