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Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice
Joint Authors
Sawa, Yoshiki
Miyagawa, Shigeru
Kimura, Atsuomi
Momozane, Toru
Fukui, Eriko
Funaki, Soichiro
Okumura, Meinoshin
Shintani, Yasushi
Kimura, Kenji
Chijimatsu, Ryota
Kanzaki, Ryu
Kanou, Takashi
Ose, Naoko
Minami, Masato
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Chronic obstructive pulmonary disease is a leading cause of mortality globally, with no effective therapy yet established.
Adipose tissue-derived stem cells (ADSCs) are useful for ameliorating lung injury in animal models.
However, whether ADSCs differentiate into functional cells remains uncertain, and no study has reported on the mechanism by which ADSCs improve lung functionality.
Thus, in this study, we examined whether ADSCs differentiate into lung alveolar cells and are able to ameliorate lung injury caused by elastase-induced emphysema in model mice.
Here, we induced ADSCs to differentiate into type 2 alveolar epithelial cells in vitro.
We demonstrated that ADSCs can differentiate into type 2 alveolar epithelial cells in an elastase-induced emphysematous lung and that ADSCs improve pulmonary function of emphysema model mice, as determined with spirometry and 129Xe MRI.
These data revealed a novel function for ADSCs in promoting repair of the damaged lung by direct differentiation into alveolar epithelial cells.
American Psychological Association (APA)
Fukui, Eriko& Funaki, Soichiro& Kimura, Kenji& Momozane, Toru& Kimura, Atsuomi& Chijimatsu, Ryota…[et al.]. 2019. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
Modern Language Association (MLA)
Fukui, Eriko…[et al.]. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
American Medical Association (AMA)
Fukui, Eriko& Funaki, Soichiro& Kimura, Kenji& Momozane, Toru& Kimura, Atsuomi& Chijimatsu, Ryota…[et al.]. Adipose Tissue-Derived Stem Cells Have the Ability to Differentiate into Alveolar Epithelial Cells and Ameliorate Lung Injury Caused by Elastase-Induced Emphysema in Mice. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209003