Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches
المؤلفون المشاركون
Varghese, Divya S.
Ansari, Suraiya A.
Alawathugoda, Thilina Thejinda
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-22
دولة النشر
مصر
عدد الصفحات
18
الملخص EN
Human embryonic stem cells (hESCs) are being utilized in diverse areas of studies such as development and disease modeling, cell replacement therapy, or drug toxicity testing because of their potential to be differentiated into any cell type in the body.
The directed differentiation of hESCs into hepatocytes could provide an invaluable source of liver cells for various liver-based applications.
Therefore, several protocols have been established in the past for hESC-hepatocyte differentiation based on the knowledge of signaling pathways and growth factors involved in different stages of embryonic hepatogenesis.
Although successful derivation of hepatocytes has been achieved through these protocols, the efficiency is not always ideal.
Herein, we have tested several combinations of published protocols, for example, growth factor vs.
small molecule and different time durations of treatment for definitive endoderm (DE) induction and further hepatocyte differentiation to develop an efficient DE induction and hepatocyte differentiation in a highly reproducible manner based on the stage-specific marker expression and functional analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varghese, Divya S.& Alawathugoda, Thilina Thejinda& Ansari, Suraiya A.. 2019. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells International،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1209204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varghese, Divya S.…[et al.]. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells International No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1209204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varghese, Divya S.& Alawathugoda, Thilina Thejinda& Ansari, Suraiya A.. Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1209204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر