Metformin Delays Satellite Cell Activation and Maintains Quiescence
المؤلفون المشاركون
Pavlidou, Theodora
Marinkovic, Milica
Rosina, Marco
Fuoco, Claudia
Vumbaca, Simone
Gargioli, Cesare
Castagnoli, Luisa
Cesareni, Gianni
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-24
دولة النشر
مصر
عدد الصفحات
19
الملخص EN
The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate.
In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue.
These disorders are associated with the depletion of the satellite cell pool or with the loss of satellite cell functionality.
Recently, the establishment and maintenance of quiescence in satellite cells have been linked to their metabolic state.
In this work, we aimed to modulate metabolism in order to preserve the satellite cell pool.
We made use of metformin, a calorie restriction mimicking drug, to ask whether metformin has an effect on quiescence, proliferation, and differentiation of satellite cells.
We report that satellite cells, when treated with metformin in vitro, ex vivo, or in vivo, delay activation, Pax7 downregulation, and terminal myogenic differentiation.
We correlate the metformin-induced delay in satellite cell activation with the inhibition of the ribosome protein RPS6, one of the downstream effectors of the mTOR pathway.
Moreover, in vivo administration of metformin induces a belated regeneration of cardiotoxin- (CTX-) damaged skeletal muscle.
Interestingly, satellite cells treated with metformin immediately after isolation are smaller in size and exhibit reduced pyronin Y levels, which suggests that metformin-treated satellite cells are transcriptionally less active.
Thus, our study suggests that metformin delays satellite cell activation and differentiation by favoring a quiescent, low metabolic state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pavlidou, Theodora& Marinkovic, Milica& Rosina, Marco& Fuoco, Claudia& Vumbaca, Simone& Gargioli, Cesare…[et al.]. 2019. Metformin Delays Satellite Cell Activation and Maintains Quiescence. Stem Cells International،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1209223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pavlidou, Theodora…[et al.]. Metformin Delays Satellite Cell Activation and Maintains Quiescence. Stem Cells International No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1209223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pavlidou, Theodora& Marinkovic, Milica& Rosina, Marco& Fuoco, Claudia& Vumbaca, Simone& Gargioli, Cesare…[et al.]. Metformin Delays Satellite Cell Activation and Maintains Quiescence. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1209223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر