A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction
المؤلفون المشاركون
Murray, Patricia
Sharkey, Jack
Wilm, Bettina
Ressel, Lorenzo
Brillant, Nathalie
Scarfe, Lauren
Park, B. Kevin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Cell-based regenerative medicine therapies require robust preclinical safety, efficacy, biodistribution, and engraftment data prior to clinical testing.
To address these challenges, we have developed an imaging toolbox comprising multispectral optoacoustic tomography and ultrasonography, which allows the degree of kidney, liver, and cardiac injury and the extent of functional recovery to be assessed noninvasively in a mouse model of multiorgan dysfunction.
This toolbox allowed us to determine the therapeutic effects of adoptively transferred macrophages.
Using bioluminescence imaging, we could then investigate the association between amelioration and biodistribution.
Macrophage therapy provided limited improvement of kidney and liver function, although not significantly so, without amelioration of histological damage.
No improvement in cardiac function was observed.
Biodistribution analysis showed that macrophages homed and persisted in the injured kidneys and liver but did not populate the heart.
Our data suggest that the limited improvement observed in kidney and liver function could be mediated by M2 macrophages.
More importantly, we demonstrate here the utility of the imaging toolbox for assessing the efficacy of potential regenerative medicine therapies in multiple organs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharkey, Jack& Ressel, Lorenzo& Brillant, Nathalie& Scarfe, Lauren& Wilm, Bettina& Park, B. Kevin…[et al.]. 2019. A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction. Stem Cells International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharkey, Jack…[et al.]. A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction. Stem Cells International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1209540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharkey, Jack& Ressel, Lorenzo& Brillant, Nathalie& Scarfe, Lauren& Wilm, Bettina& Park, B. Kevin…[et al.]. A Noninvasive Imaging Toolbox Indicates Limited Therapeutic Potential of Conditionally Activated Macrophages in a Mouse Model of Multiple Organ Dysfunction. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر