Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma
المؤلفون المشاركون
Djonov, V.
Simovic Markovic, Bojana
Arsenijevic, Aleksandar
Harrell, C. Randall
Fellabaum, Crissy
Volarevic, Vladislav
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-27
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Glaucoma represents a group of progressive optic neuropathies characterized by gradual loss of retinal ganglion cells (RGCs), the neurons that conduct visual information from the retina to the brain.
Elevated intraocular pressure (IOP) is considered the main reason for enhanced apoptosis of RGCs in glaucoma.
Currently used therapeutic agents are not able to repopulate and/or regenerate injured RGCs and, therefore, are ineffective in most patients with advanced glaucoma.
Accordingly, several new therapeutic approaches, including stem cell-based therapy, have been explored for the glaucoma treatment.
In this review article, we emphasized current knowledge regarding molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cells (MSCs) and their secretome in the treatment of glaucoma.
MSCs produce neurotrophins and in an exosome-dependent manner supply injured RGCs with growth factors enhancing their survival and regeneration.
Additionally, MSCs are able to generate functional RGC-like cells and induce proliferation of retinal stem cells.
By supporting integrity of trabecular meshwork, transplanted MSCs alleviate IOP resulting in reduced loss of RGCs.
Moreover, MSCs are able to attenuate T cell-driven retinal inflammation providing protection to the injured retinal tissue.
In summing up, due to their capacity for neuroprotection and immunomodulation, MSCs and their secretome could be explored in upcoming clinical studies as new therapeutic agents for glaucoma treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Harrell, C. Randall& Fellabaum, Crissy& Arsenijevic, Aleksandar& Simovic Markovic, Bojana& Djonov, V.& Volarevic, Vladislav. 2019. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Harrell, C. Randall…[et al.]. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Harrell, C. Randall& Fellabaum, Crissy& Arsenijevic, Aleksandar& Simovic Markovic, Bojana& Djonov, V.& Volarevic, Vladislav. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209606
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر