Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma
Joint Authors
Djonov, V.
Simovic Markovic, Bojana
Arsenijevic, Aleksandar
Harrell, C. Randall
Fellabaum, Crissy
Volarevic, Vladislav
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-27
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Glaucoma represents a group of progressive optic neuropathies characterized by gradual loss of retinal ganglion cells (RGCs), the neurons that conduct visual information from the retina to the brain.
Elevated intraocular pressure (IOP) is considered the main reason for enhanced apoptosis of RGCs in glaucoma.
Currently used therapeutic agents are not able to repopulate and/or regenerate injured RGCs and, therefore, are ineffective in most patients with advanced glaucoma.
Accordingly, several new therapeutic approaches, including stem cell-based therapy, have been explored for the glaucoma treatment.
In this review article, we emphasized current knowledge regarding molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cells (MSCs) and their secretome in the treatment of glaucoma.
MSCs produce neurotrophins and in an exosome-dependent manner supply injured RGCs with growth factors enhancing their survival and regeneration.
Additionally, MSCs are able to generate functional RGC-like cells and induce proliferation of retinal stem cells.
By supporting integrity of trabecular meshwork, transplanted MSCs alleviate IOP resulting in reduced loss of RGCs.
Moreover, MSCs are able to attenuate T cell-driven retinal inflammation providing protection to the injured retinal tissue.
In summing up, due to their capacity for neuroprotection and immunomodulation, MSCs and their secretome could be explored in upcoming clinical studies as new therapeutic agents for glaucoma treatment.
American Psychological Association (APA)
Harrell, C. Randall& Fellabaum, Crissy& Arsenijevic, Aleksandar& Simovic Markovic, Bojana& Djonov, V.& Volarevic, Vladislav. 2019. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
Modern Language Association (MLA)
Harrell, C. Randall…[et al.]. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
American Medical Association (AMA)
Harrell, C. Randall& Fellabaum, Crissy& Arsenijevic, Aleksandar& Simovic Markovic, Bojana& Djonov, V.& Volarevic, Vladislav. Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1209606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209606